منابع مشابه
Formin’ the cytokinetic ring
A ll animal and fungal cells assemble a contractile actomyosin ring to divide themselves in two at the end of mitosis. The rings are constructed from actin fi laments formed de novo at the division site and from fi laments that are assembled elsewhere in the cell and transported to the cleavage zone. Both types of fi lament are generated by actinnucleating formin proteins, but whether one sourc...
متن کاملFormin’ actin in the nucleus
Many if not most proteins can, under certain conditions, change cellular compartments, such as, for example, shuttling from the cytoplasm to the nucleus. Thus, many proteins may exert functions in various and very different subcellular locations, depending on the signaling context. A large amount of actin regulatory proteins has been detected in the mammalian cell nucleus, although their potent...
متن کاملFormin a shmoo
ytoplasmic structures are sites of active mammalian mRNA decay, according to Cougot et al. (page 31). The group had previously identified cytoplasmic foci that included two human mRNA decapping enzymes. They now add subunits of a deadenylase, exonuclease, and possible helicase to the list of proteins found at these sites. After inhibition of a 5 –3 exonuclease, poly(A) RNA accumulates at the sa...
متن کاملLamellipodia fight back formin
Lamellipodia fight back formin T he actin-organizing activities in a reaching lamellipod fi ght back the trailing lamella, say Sarmiento et al. The feedback might coordinate inchworm-like migration in normal and cancerous cells. Tumor cells such as breast cancer carcinomas become dangerously motile because they have hyperactive actin-poly-merizing pathways that respond to epidermal growth facto...
متن کاملFormin’ muscle sarcomeres
The Fuzzy logistics of intraflagellar transpor t T he planar cell polarity protein Fuzzy (Fuz) promotes ciliogenesis by delivering intrafl agellar transport (IFT) proteins to the basal bodies of primary cilia, Brooks and Wallingford report. Fuz is required for cilia assembly in frogs and mice, but how it supports ciliogenesis is unknown. The protein has no obvious functional domains, though bio...
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ژورنال
عنوان ژورنال: Immunity
سال: 2007
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2007.02.007